Bioreactor Fermenter

The microbial fermentation is the most applied method in biotechnology, and nowadays it is distinguished by innumerable applications. An example are riboflavin, beta carotene and vitamin B12

The typical batch mode fermentation is presented by the following stages: addition of a solution rich in nutrients, inoculation of microorganisms, injection of foam inhibitor and oxygen ( many microorganisms used in bioprocessing are aerobic). In his type of fermentation systems, the accumulation of waste products and multiplication of the microorganisms provokes the variation of conditions during the fermentation process.

The most frequent problems occurred during the fermentation process is contamination due to an inadequate sterilization or loss of sterility during the process. The use of reliable and high-performance systems provide safety conditions for high quality production.

Technical informations

Features:

Volume: 150 - 6.000 liters; Design conforms to ASME BPE; Skid-mounted structure; Tank jacketed and insulated
- CIP/SIP design; H/D 3:1, 2:1; Pressure -1/+3 bars

The control system is totally automated, the PLC controls and records all functions and data:
       - Agitation speed; Oxygen level;  Temperature; Pressure regulation in exhaust pipe; Addition of nutrients; Product harvest; Sterilization of the nutrient medium; Steam sterilization of the fermenter

        - Vertical agitator with mechanical seal and motor gear drive.

Materials:

Parts in contact with the media: St.St.S 316L.
Internal surface: Ra < 0,4.
Single mechanical seal (dry running).
Sterile sampling system.